There are many how-to's online which tell you how to disable Chrome's cache in Developer mode. What if you want to completely disable Chrome's cache without using Developer mode? You can do this if you launch Chrome from the command line. Simply run:
/Applications/Google\ Chrome-nocache.app/Contents/MacOS/Google\ Chrome --disk-cache-dir=/dev/null
If you are a Keyboard Maestro user, setting this up with a keyboard shortcut is a relatively simple task.